2-Methanesulfonylacetic acid → N-[2-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]quinazolin-5-yl]oxypropyl]-2-methylsulfonylacetamide
Reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][C:6](=[O:7])[OH:8].[NH2:9][CH2:10][CH:11]([O:12][c:13]1[c:14]2[c:15]([NH:23][c:24]3[cH:25][c:26]([Cl:38])[c:27]([O:30][CH2:31][c:32]4[n:33][cH:34][cH:35][cH:36][cH:37]4)[cH:28][cH:29]3)[n:16][cH:17][n:18][c:19]2[cH:20][cH:21][cH:22]1)[CH3:39]>>[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][C:6](=[O:8])[NH:9][CH2:10][CH:11]([O:12][c:13]1[c:14]2[c:15]([NH:23][c:24]3[cH:25][c:26]([Cl:38])[c:27]([O:30][CH2:31][c:32]4[n:33][cH:34][cH:35][cH:36][cH:37]4)[cH:28][cH:29]3)[n:16][cH:17][n:18][c:19]2[cH:20][cH:21][cH:22]1)[CH3:39]Participants
3
Sources & evidence
- ORD record
- ord-a64a16bce2be4d8ebb4c386c18480236
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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