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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12246Generated: October 26, 2026

1-Methylpiperazine → 6,6-dimethyl-4-[-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

https://huagongshe.com/reaction/12246

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant[5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acidHCID 59337527—
Product6,6-dimethyl-4-[-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amideHCID 6716613512%

Reaction Steps

The desired compound was prepared using [5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid and 1-methyl piperazine following Method F in 12% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07727985B2
Source datasetuspto-grants-2010_06
ORD IDord-f451cb243ac244ca9c1117bdd2491195
Source noteuspto-grants-2010_06