Pyridine → 3-pyridylmethyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate

HRID 1224765Notes

Reaction equation

HRID 1224765 reaction equation
[C:32]([O:33][c:35]1[cH:36][cH:37][c:38]([N+:39]([O-:40])=[O:41])[cH:42][cH:51]1)(=[O:34])[O:43][CH2:44][c:45]1[cH:46][n:47][cH:48][cH:49][cH:50]1.[Cl:52][CH2:53][Cl:54].[NH2:1][c:2]1[c:3]([O:24][CH3:25])[cH:4][c:5](-[c:8]2[cH:9][n:10]([CH:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1.[cH:26]1[cH:27][cH:28][n:29][cH:30][cH:31]1>>[NH:1]([c:2]1[c:3]([O:24][CH3:25])[cH:4][c:5](-[c:8]2[cH:9][n:10]([CH:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:11]3[n:12][cH:13][n:14][c:15]([NH2:17])[c:16]23)[cH:6][cH:7]1)[C:32](=[O:33])[O:43][CH2:44][c:45]1[cH:46][n:47][cH:48][cH:49][cH:50]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 22729826HCID 22729826, compoundHCID 227363445-(4-amino-3-methoxyphenyl)-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Product 1

HCID 227362193-pyridylmethyl N-[4-(4-amino-7-tetrahydro-2H-4-pyranyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate

Sources & evidence

ORD record
ord-f862a9271c184ca18b8eb8cd8a96b905
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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