Sodium ion → tert-Butyl [1-[[3-(trifluoromethyl)phenyl]methyl]azetidin-3-yl]carbamate

HRID 1225231Notes

Reaction equation

HRID 1225231 reaction equation
[C:25]([O:26][BH-:27]([O:28][C:29](=[O:30])[CH3:31])[O:32][C:33](=[O:34])[CH3:35])(=[O:36])[CH3:37].[Cl:39][CH:40]([Cl:41])[CH3:42].[Cl:43][CH2:44][Cl:45].[F:13][C:14]([c:15]1[cH:16][c:17]([CH:18]=[O:19])[cH:20][cH:21][cH:22]1)([F:23])[F:24].[NH:1]1[CH2:2][CH:3]([NH:5][C:6]([O:7][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:12])[CH2:4]1.[Na+:38]>>[N:1]1([CH2:18][c:17]2[cH:16][c:15]([C:14]([F:13])([F:23])[F:24])[cH:22][cH:21][cH:20]2)[CH2:2][CH:3]([NH:5][C:6]([O:7][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:12])[CH2:4]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 6344DichloromethaneHCID 63651,1-DichloroethaneHCID 679903-(Trifluoromethyl)benzaldehydeHCID 15194053-Aminoazetidine, 3-BOC protectedHCID 2724942Triacetoxyborohydride

Product 1

HCID 67445744tert-Butyl [1-[[3-(trifluoromethyl)phenyl]methyl]azetidin-3-yl]carbamate

Sources & evidence

ORD record
ord-e010c9491113482db9748ba69b52170f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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