Acetate → N-[1-(5-ethenyl-2-pyridinyl)ethyl]-2-[4-(5-methyl-1,2-oxazol-4-yl)phenyl]acetamide

HRID 1225769Notes

Reaction equation

HRID 1225769 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH3:9])[NH:10][C:11]([CH2:12][c:13]2[cH:14][cH:15][c:16](-[c:19]3[cH:20][n:21][o:22][c:23]3[CH3:24])[cH:17][cH:18]2)=[O:25])[n:6][cH:7]1.[CH3:44][C:45]#[N:46].[CH:26](=[CH2:27])[B:28]1[O:29][C:30]([CH3:31])([CH3:32])[C:33]([CH3:34])([CH3:35])[O:36]1.[CH:37]([NH:38][CH:39]([CH3:40])[CH3:41])([CH3:42])[CH3:43].[O-:49][C:50]([CH3:51])=[O:52].[O-:53][C:54]([CH3:55])=[O:56].[OH2:47].[Pd+2:48]>>[c:2]1([CH:26]=[CH2:27])[cH:3][cH:4][c:5]([CH:8]([CH3:9])[NH:10][C:11]([CH2:12][c:13]2[cH:14][cH:15][c:16](-[c:19]3[cH:20][n:21][o:22][c:23]3[CH3:24])[cH:17][cH:18]2)=[O:25])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 962WaterHCID 6342AcetonitrileHCID 7912DiisopropylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 52330122-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 91204965N-[1-(5-bromo-2-pyridinyl)ethyl]-2-[4-(5-methyl-1,2-oxazol-4-yl)phenyl]acetamide

Product 1

HCID 91098957N-[1-(5-ethenyl-2-pyridinyl)ethyl]-2-[4-(5-methyl-1,2-oxazol-4-yl)phenyl]acetamide

Sources & evidence

ORD record
ord-1d72efd8f7324a24b9514e19afbfcf32
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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