Dichloromethane → 4-(4-bromo-1-methylpyrazol-5-yl)-5-chloro-N-[1-cyclohexyl-3-(1,3-dioxoisoindol-2-yl)propan-2-yl]thiophene-2-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][n:4][n:5]([CH3:16])[c:6]1-[c:7]1[cH:8][c:9]([C:13](=[O:14])[OH:15])[s:10][c:11]1[Cl:12].[Br:45][P+:46]([N:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1)([N:52]1[CH2:53][CH2:54][CH2:55][CH2:56]1)[N:57]1[CH2:58][CH2:59][CH2:60][CH2:61]1.[Cl:62][CH2:63][Cl:64].[NH2:17][CH:18]([CH2:19][N:20]1[C:21](=[O:30])[c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[C:28]1=[O:29])[CH2:31][CH:32]1[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1.[P-:38]([F:39])([F:40])([F:41])([F:42])([F:43])[F:44]>>[Br:1][c:2]1[cH:3][n:4][n:5]([CH3:16])[c:6]1-[c:7]1[cH:8][c:9]([C:13](=[O:15])[NH:17][CH:18]([CH2:19][N:20]2[C:21](=[O:30])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[C:28]2=[O:29])[CH2:31][CH:32]2[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]2)[s:10][c:11]1[Cl:12]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-8a80129519224e59ac692d757fd63b88
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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