4-Bromo-2,6-difluorobenzoic acid → (4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:12])[c:5]([C:6](=[O:7])[OH:8])[c:9]([F:11])[cH:10]1.[CH:13]1([c:16]2[cH:17][cH:18][c:19]([N:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[n:20][cH:21]2)[CH2:14][CH2:15]1>>[Br:1][c:2]1[cH:3][c:4]([F:12])[c:5]([C:6](=[O:8])[N:25]2[CH2:24][CH2:23][N:22]([c:19]3[cH:18][cH:17][c:16]([CH:13]4[CH2:14][CH2:15]4)[cH:21][n:20]3)[CH2:27][CH2:26]2)[c:9]([F:11])[cH:10]1Participants
3
Sources & evidence
- ORD record
- ord-89c957dad13f4f969e1695230b17647d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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