Pyridine → N-[4-acetyl-5-(2-methanesulfonylaminoethyl)-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2-phenylpropanamide

HRID 1226345Notes

Reaction equation

HRID 1226345 reaction equation
[C:23]([CH3:24])(=[O:25])[N:26]1[C:27]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)([CH2:38][CH2:39][NH:40][S:41](=[O:42])(=[O:43])[CH3:44])[S:28][C:29]([NH2:31])=[N:30]1.[S:51]([Cl:52])([Cl:53])=[O:54].[c:12]1([CH:13]([CH3:14])[C:15]([OH:16])=[O:17])[cH:18][cH:19][cH:20][cH:21][cH:22]1.[c:1]1([CH:7]([C:8](=[O:9])[Cl:10])[CH3:11])[cH:2][cH:3][cH:4][cH:5][cH:6]1.[cH:45]1[cH:46][cH:47][n:48][cH:49][cH:50]1>>[c:1]1([CH:7]([C:8](=[O:9])[NH:31][C:29]2=[N:30][N:26]([C:23]([CH3:24])=[O:25])[C:27]([c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)([CH2:38][CH2:39][NH:40][S:41](=[O:42])(=[O:43])[CH3:44])[S:28]2)[CH3:11])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 102962-Phenylpropionic acidHCID 24386Thionyl ChlorideHCID 2760403Hydratropoyl chlorideHCID 67039184N-[2-(3-acetyl-5-amino-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)ethyl]methanesulfonamide

Product 1

HCID 67039180N-[4-acetyl-5-(2-methanesulfonylaminoethyl)-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl]-2-phenylpropanamide

Sources & evidence

ORD record
ord-4186cf7d8ffb47b7a3f97dfc4665e971
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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