Ethyl chloroformate → 1-(Ethoxycarbonyl)piperidin-4-yl 7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinoline-2(1h)-carboxylate
Reaction equation
[Cl:1][C:2](=[O:3])[O:4][CH2:5][CH3:6].[NH2:7][c:8]1[n:9][c:10]([N:33]2[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]3[c:22]([cH:23]2)[CH2:21][N:20]([C:24](=[O:25])[O:26][CH:27]2[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]2)[CH2:19][CH2:18]3)[n:13]1>>[C:2](=[O:3])([O:4][CH2:5][CH3:6])[N:30]1[CH2:29][CH2:28][CH:27]([O:26][C:24]([N:20]2[CH2:19][CH2:18][c:17]3[cH:16][cH:15][c:14](-[c:12]4[cH:11][c:10]([N:33]5[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]5)[n:9][c:8]([NH2:7])[n:13]4)[cH:23][c:22]3[CH2:21]2)=[O:25])[CH2:32][CH2:31]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-17723b21b92a465da8048239d3e62d53
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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