2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{5-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridin-2-yl]-thiophen-2-yl}-pyrimidin-2-ylamine

HRID 1226772Notes

Reaction equation

HRID 1226772 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([CH3:21])[cH:10][c:11](-[c:13]3[cH:14][c:15]([Cl:20])[c:16]([Cl:19])[cH:17][cH:18]3)[cH:12]2)[s:6]1.[NH2:22][c:23]1[n:24][cH:25][c:26]([B:29]2[O:30][C:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[O:37]2)[cH:27][n:28]1>>[c:2]1(-[c:26]2[cH:25][n:24][c:23]([NH2:22])[n:28][cH:27]2)[cH:3][cH:4][c:5](-[c:7]2[n:8][c:9]([CH3:21])[cH:10][c:11](-[c:13]3[cH:14][c:15]([Cl:20])[c:16]([Cl:19])[cH:17][cH:18]3)[cH:12]2)[s:6]1

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 574688012-(5-Bromo-thiophen-2-yl)-4-(3,4-dichlorophenyl)-6-methyl-pyridine

Product 1

HCID 247605135-{5-[4-(3,4-Dichloro-phenyl)-6-methyl-pyridin-2-yl]-thiophen-2-yl}-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-5689dcb67228479fa2422e8398d98a2b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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