4-Fluorobenzyl bromide → ethyl 2-(3-(4-fluorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl)-4-methylthiazole-5-carboxylate

HRID 1226825Notes

Reaction equation

HRID 1226825 reaction equation
[Br:13][CH2:14][c:15]1[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]1.[CH3:22][c:23]1[n:24][c:25]([N:33]2[C:34](=[O:39])[NH:35][CH2:36][CH2:37][CH2:38]2)[s:26][c:27]1[C:28](=[O:29])[O:30][CH2:31][CH3:32].[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][Br:10])[cH:11][cH:12]1>>[CH2:14]([c:15]1[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]1)[N:35]1[C:34](=[O:39])[N:33]([c:25]2[n:24][c:23]([CH3:22])[c:27]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[s:26]2)[CH2:38][CH2:37][CH2:36]1

Participants

4

Reactant 3

HCID 680214-Fluorobenzyl bromideHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 58031510ethyl 4-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)thiazole-5-carboxylate

Product 1

HCID 58031526ethyl 2-(3-(4-fluorobenzyl)-2-oxotetrahydropyrimidin-1(2H)-yl)-4-methylthiazole-5-carboxylate

Sources & evidence

ORD record
ord-f7cf16a328b04e2798c92149dd6df19b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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