6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide → HCID 178463409, compound

HRID 12272Notes

Reaction equation

HRID 12272 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[C:13](=[O:27])[NH:14][N:15]=[C:16]([C:18]2[CH:23]=[CH:22][N:21]=[C:20]([NH:24][CH2:25][CH3:26])[N:19]=2)[CH:17]=1)=O>C(O)(=O)C>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]2[NH:9][C:10]([C:12]3[C:13](=[O:27])[NH:14][N:15]=[C:16]([C:18]4[CH:23]=[CH:22][N:21]=[C:20]([NH:24][CH2:25][CH3:26])[N:19]=4)[CH:17]=3)=[N:1][C:2]=2[CH:7]=1

Participants

3

Reactant 1

HCID 866116046-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2amino-4-chlorophenyl)amide

Product 1

HCID 178463409HCID 178463409, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6-(2-Ethylaminopyrimidin-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-4-chlorophenyl)amide (50 mg) are stirred in 1 ml of glacial acetic acid at 100° C. for 3 hours. After cooling, the precipitate is filtered off with suction, stirred with aqueous sodium bicarbonate solution and again filtered off with suction, washed with water and dried in vacuo.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off with suction
  3. filtrationagain filtered off with suction
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-72c1b37601314bc3b8dc57e3b5fa4dc1
Source dataset
uspto-grants-2010_06
Patent number
US07727989B2

Reaction notes

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