6-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-5-chlorophenyl)amide → HCID 136343866, compound

HRID 12273Notes

Reaction equation

HRID 12273 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[C:13](=[O:19])[NH:14][N:15]=[C:16]([Cl:18])[CH:17]=1)=O.NC1C=C(Cl)C=CC=1NC(C1C(=O)NN=C(Cl)C=1)=O>C(O)(=O)C>[Cl:18][C:16]1[CH:17]=[C:12]([C:10]2[NH:9][C:3]3[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=3[N:1]=2)[C:13](=[O:19])[NH:14][N:15]=1

Participants

4

Reactant 2

HCID 866116056-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-5-chlorophenyl)amideHCID 866116066-Chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-4-chlorophenyl)amide

Product 1

HCID 136343866HCID 136343866, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-5-chlorophenyl)amide and 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (2-amino-4-chlorophenyl)amide (1.0 g; 1.67 mmol) is dissolved in 100 ml of glacial acetic acid and heated at 120° C. for 90 min. A precipitate separates out on cooling and is filtered off with suction and dried in vacuo at 40° C.

Workup

  1. temperatureon cooling
  2. filtrationis filtered off with suction
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-669cdacc1e58420e9b6082d0b7ac8879
Source dataset
uspto-grants-2010_06
Patent number
US07727989B2

Reaction notes

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