1-(2,5-Difluorobenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine → 5-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]-nicotinic acid ethyl ester

HRID 1227335Notes

Reaction equation

HRID 1227335 reaction equation
[CH2:21]([CH3:22])[O:23][C:24]([c:25]1[cH:26][n:27][cH:28][c:29]([B:31]2[O:32][C:33]([CH3:34])([CH3:35])[CH:36]([CH3:37])[O:38]2)[cH:30]1)=[O:39].[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1>>[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:29]4[cH:28][n:27][cH:26][c:25]([C:24]([O:23][CH2:21][CH3:22])=[O:39])[cH:30]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 578860131-(2,5-Difluorobenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazineHCID 670917915-(4,4,5-Trimethyl-[1,3,2]dioxaborolan-2-yl)-nicotinic acid ethyl ester

Product 1

HCID 248533335-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]-nicotinic acid ethyl ester

Sources & evidence

ORD record
ord-c7ad1a6f052740799fcab04ae907e8aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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