3-Hydroxyazetidine → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine
Reaction equation
[CH2:6]([c:7]1[cH:8][cH:9][cH:10][cH:11][cH:12]1)[C:13]1([OH:14])[CH:15]=[CH:16][CH:17]=[CH:18][CH2:19]1.[CH:39]([c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1)([c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)[N:52]1[CH2:53][CH:54]([O:56][CH:57]([c:58]2[cH:59][cH:60][c:61]([Cl:62])[cH:63][cH:64]2)[c:65]2[cH:66][cH:67][c:68]([Cl:69])[cH:70][c:71]2[Cl:72])[CH2:55]1.[F:20][C:21]([c:22]1[c:23]([CH:24]([c:25]2[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]2)[OH:32])[cH:33][cH:34][cH:35][cH:36]1)([F:37])[F:38].[NH:1]1[CH2:2][CH:3]([OH:4])[CH2:5]1>>[F:20][C:21]([c:22]1[c:23]([CH:24]([c:25]2[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]2)[O:32][CH:54]2[CH2:53][N:52]([CH:39]([c:40]3[cH:41][cH:42][cH:43][cH:44][cH:45]3)[c:46]3[cH:47][cH:48][cH:49][cH:50][cH:51]3)[CH2:55]2)[cH:33][cH:34][cH:35][cH:36]1)([F:37])[F:38]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-484955502aa94924bab590c93f80fcab
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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