Acetonitrile → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-methylamino-1,3,3a,4,7,7a-hexahydro-isoindol-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

HRID 1227977Notes

Reaction equation

HRID 1227977 reaction equation
[CH3:20][NH:21][CH:22]1[CH:23]2[CH2:24][NH:25][CH2:26][CH:27]2[CH2:28][CH:29]=[CH:30]1.[CH3:31][C:32]#[N:33].[Cl:1][c:2]1[c:3]([F:19])[cH:4][c:5]2[c:6](=[O:18])[c:7]([C:15](=[O:16])[OH:17])[cH:8][n:9]([CH:12]3[CH2:13][CH2:14]3)[c:10]2[n:11]1>>[c:2]1([N:25]2[CH2:24][CH:23]3[CH:22]([NH:21][CH3:20])[CH:30]=[CH:29][CH2:28][CH:27]3[CH2:26]2)[c:3]([F:19])[cH:4][c:5]2[c:6](=[O:18])[c:7]([C:15](=[O:16])[OH:17])[cH:8][n:9]([CH:12]3[CH2:13][CH2:14]3)[c:10]2[n:11]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 110551427-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 15283247HCID 15283247, compound

Product 1

HCID 193743901-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-methylamino-1,3,3a,4,7,7a-hexahydro-isoindol-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-644c0167f32c4328b9be853ed28e2856
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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