5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → 5-{1-[4-(4-Chloro-phenyl)-6-cyclopropyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

HRID 1228431Notes

Reaction equation

HRID 1228431 reaction equation
[Br:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH:20]3[CH2:21][CH2:22]3)[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1.[NH2:23][c:24]1[n:25][cH:26][c:27]([B:30]2[O:31][C:32]([CH3:33])([CH3:34])[C:35]([CH3:36])([CH3:37])[O:38]2)[cH:28][cH:29]1>>[c:2]1(-[c:27]2[cH:26][n:25][c:24]([NH2:23])[cH:29][cH:28]2)[n:3][cH:4][n:5](-[c:7]2[n:8][c:9]([CH:20]3[CH2:21][CH2:22]3)[cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:12]2)[cH:6]1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 574687382-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-cyclopropyl-pyrimidine

Product 1

HCID 602093665-{1-[4-(4-Chloro-phenyl)-6-cyclopropyl-pyrimidin-2-yl]-1H-imidazol-4-yl}-pyridin-2-ylamine

Sources & evidence

ORD record
ord-3edbace7637a496288992f0a6c128fdc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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