Sodium ion → Methyl 2'-fluoro-2-iodo-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

HRID 1228696Notes

Reaction equation

HRID 1228696 reaction equation
[CH3:21][O:22][CH2:23][CH2:24][O:25][CH3:26].[I-:37].[N:32]([O-:33])=[O:34].[NH2:1][c:2]1[c:3](-[c:12]2[c:13]([F:20])[cH:14][cH:15][c:16]([O:18][CH3:19])[cH:17]2)[cH:4][cH:5][c:6]([C:8](=[O:9])[O:10][CH3:11])[cH:7]1.[Na+:35].[Na+:36].[OH2:38].[S:27](=[O:28])(=[O:29])([OH:30])[OH:31]>>[c:2]1([I:37])[c:3](-[c:12]2[c:13]([F:20])[cH:14][cH:15][c:16]([O:18][CH3:19])[cH:17]2)[cH:4][cH:5][c:6]([C:8](=[O:9])[O:10][CH3:11])[cH:7]1

Participants

8

Reactant 7

HCID 923Sodium ion2×HCID 946NitriteHCID 962WaterHCID 1118Sulfuric AcidHCID 80711,2-DimethoxyethaneHCID 30165Iodide IonHCID 57705693Methyl 2-amino-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Product 1

HCID 57705628Methyl 2'-fluoro-2-iodo-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Sources & evidence

ORD record
ord-150abf7c3e0c42ecaba9be974f369002
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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