2-Piperazin-1-yl-thiazole-5-carbonitrile → 2-{4-[5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoyl]-piperazin-1-yl}-thiazole-5-carbonitrile

HRID 122875Notes

Reaction equation

HRID 122875 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:11])[OH:12])[cH:13]1.[N:21]1([c:27]2[s:28][c:29]([C:32]#[N:33])[cH:30][n:31]2)[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]1>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:12])[N:24]2[CH2:23][CH2:22][N:21]([c:27]3[s:28][c:29]([C:32]#[N:33])[cH:30][n:31]3)[CH2:26][CH2:25]2)[cH:13]1

Participants

3

Reactant 2

HCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrileHCID 211003065-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

Product 1

HCID 115332362-{4-[5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoyl]-piperazin-1-yl}-thiazole-5-carbonitrile

Sources & evidence

ORD record
ord-748854d5b9a94f9791ddfba72dae91a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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