2-(2-Chloro-pyridin-4-yl)-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine → 5-{4-[4-(3,4-Difluoro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-pyridin-2-yl}-thiophene-2-sulfonic acid tert-butyl amide

HRID 1228826Notes

Reaction equation

HRID 1228826 reaction equation
[C:26]([CH3:27])([CH3:28])([CH3:29])[NH:30][S:31](=[O:32])(=[O:33])[c:34]1[s:35][c:36]([B:39]2[O:40][C:41]([CH3:42])([CH3:43])[C:44]([CH3:45])([CH3:46])[O:47]2)[cH:37][cH:38]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([C:22]([F:23])([F:24])[F:25])[cH:11][c:12](-[c:14]3[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]3)[n:13]2)[cH:7]1>>[c:2]1(-[c:36]2[s:35][c:34]([S:31]([NH:30][C:26]([CH3:27])([CH3:28])[CH3:29])(=[O:32])=[O:33])[cH:38][cH:37]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[n:9][c:10]([C:22]([F:23])([F:24])[F:25])[cH:11][c:12](-[c:14]3[cH:15][c:16]([F:21])[c:17]([F:20])[cH:18][cH:19]3)[n:13]2)[cH:7]1

Participants

3

Reactant 2

HCID 574688132-(2-Chloro-pyridin-4-yl)-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidineHCID 57468817N-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-sulfonamide

Product 1

HCID 602094845-{4-[4-(3,4-Difluoro-phenyl)-6-trifluoromethyl-pyrimidin-2-yl]-pyridin-2-yl}-thiophene-2-sulfonic acid tert-butyl amide

Sources & evidence

ORD record
ord-ea4510dfc3944b74922666a49275b70b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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