HRID12294

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6329

Methylamine

CH5N

HCID8028

Tetrahydrofuran

C4H8O

HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：COc1cc(-c2cc(-c3nc4ccccc4n3COCC[Si](C)(C)C)c(=O)n(COCC[Si](C)(C)C)n2)cc(C=O)c1OCOCC[Si](C)(C)C

HCID86611611

未命名化合物

PRODUCTS

生成物

结构：CNCc1cc(-c2cc(-c3nc4ccccc4n3COCC[Si](C)(C)C)c(=O)n(COCC[Si](C)(C)C)n2)cc(OC)c1OCOCC[Si](C)(C)C

HCID68680816

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

200 mg of methoxy-5-{6-oxo-1-(2-trimethylsilanylethoxymethyl)-5-[1-(2-trimethylsilanylethoxymethyl)-1H-benzimidazol-2-yl]-1,6-dihydropyridazin-3-yl}-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde are dissolved in 4.5 ml of methanol and methylamine (0.146 ml of a THF solution), and 18.4 mg of sodium cyanoborohydride are added, followed by 17 mg of acetic acid. After stirring at room temperature for 16 hours, the volatile components are distilled off and the crude product is employed without further purification for the next reaction.

WORKUP

后处理

distillationthe volatile components are distilled off
customthe crude product is employed without further purification for the next reaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3838062fb5794b499372a71d6efce843
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07727989B2
来源说明: uspto-grants-2010_06

反应 SMILES

[CH3:1][O:2][C:3]1[C:4]([O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:51])([CH3:50])[CH3:49])=[C:5]([CH:8]=[C:9]([C:11]2[CH:16]=[C:15]([C:17]3[N:21]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:20]4[CH:30]=[CH:31][CH:32]=[CH:33][C:19]=4[N:18]=3)[C:14](=[O:34])[N:13]([CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:42])([CH3:41])[CH3:40])[N:12]=2)[CH:10]=1)C=O.[CH3:52][NH2:53].[CH2:54]1COCC1.C([BH3-])#N.[Na+]>CO.C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([C:11]2[CH:16]=[C:15]([C:17]3[N:21]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:20]4[CH:30]=[CH:31][CH:32]=[CH:33][C:19]=4[N:18]=3)[C:14](=[O:34])[N:13]([CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:40])([CH3:41])[CH3:42])[N:12]=2)[CH:8]=[C:5]([CH2:52][NH:53][CH3:54])[C:4]=1[O:43][CH2:44][O:45][CH2:46][CH2:47][Si:48]([CH3:51])([CH3:50])[CH3:49]