反应详情

4-Chlorophenylacetic acid (5.0 g) was dissolved in 10% hydrogen chloride-methanol solution (50 ml) and heated under reflex for 14 hours. The solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution was added to the residue, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure to provide methyl 2-(4-chlorophenyl)acetate (5.35 g) as a colorless, oily substance.

1. temperatureheated under reflex for 14 hours
2. customThe solvent then was removed under reduced pressure and saturated sodium hydrogencarbonate solution
3. additionwas added to the residue
4. extractionfollowed by extraction with ethyl acetate
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate and condensed under reduced pressure