HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Bis(4-fluorophenyl)acetic acid → 2,2-Bis(4-fluorophenyl)-N-methyl-N-[3-(4-(6-fluoro-3-pyridinyl)piperidin-1-yl)propyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Bis(4-fluorophenyl)acetic acid | HCID 13511684 | — |
| Reactant | 3H-spiro(2-benzofuran-1,4'-piperidine) hydrochloride | HCID 22509330 | — |
| Reactant | 2-Fluoro-5-piperidin-4-ylpyridine | HCID 23092009 | — |
| Reactant | 2-(3,4-Difluorophenyl)-2-(2-oxo-1-pyrrolidinyl)acetic acid | HCID 23092021 | — |
| Product | 2,2-Bis(4-fluorophenyl)-N-methyl-N-[3-(4-(6-fluoro-3-pyridinyl)piperidin-1-yl)propyl]acetamide | HCID 10480356 | — |
Reaction Steps
Example 9 was repeated except that spiro[isobenzofuran-1(3H), 4′-piperidine] hydrochloride which was used in Example 9-(2) was replaced with 4-(6-fluoro-3-pyridinyl)piperidine, and 2-(3,4-difluorophenyl)-2-(2-oxo-1-pyrrolidinyl)acetic acid which was used in Example 9-(4), with 2,2-bis(4-fluorophenyl)acetic acid, to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727998B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-2755bc43f82549f695ad2387daaac869 |
| Source note | uspto-grants-2010_06 |