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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1230515Generated: November 4, 2026

Acetic Acid → 3-[3-(tert-Butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one

https://huagongshe.com/reaction/1230515

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantWaterHCID 962—
Reactanttert-Butyl methyl etherHCID 15413—
ReactantFluoride IonHCID 28179—
ReactantTributylammoniumHCID 3724478—
ReactantBistrimethylsilylacetamidHCID 11708267—
Reactant3-(5-(Tert-butyldimethylsilanyloxy)-5-(4-fluorophenyl)-2-[(4-fluorophenyl-amino)-(4-hydroxyphenyl)methyl]pentanoyl)-4-phenyloxazolidin-2-oneHCID 22252047—
Product3-[3-(tert-Butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-oneHCID 22252074—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (5/10)
ORD IDord-dfb73d145e774cb5b378aa7740c0d5e6
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (5/10)