反应详情

3.85 g (12.3 mM) of silver sulfate are added, with stirring and at room temperature, to a solution of 2 g (12.3 mM) of 5-amino-2-(trifluoromethyl)pyridine in 100 ml of ethanol. 3.13 g of iodine are then added and the reaction mixture is stirred at room temperature for 24 hours. The solid in suspension in the medium is removed by filtration and the filtrate is concentrated under reduced pressure. The evaporation residue is taken up in 200 ml of dichloromethane and washed with 5% sodium hydroxide solution, and then with water and dried over magnesium sulfate. The solution obtained is concentrated under reduced pressure and 3.42 g of the expected compound are thus obtained in the form of a pink solid (yield=96%).

1. customThe solid in suspension in the medium is removed by filtration
2. concentrationthe filtrate is concentrated under reduced pressure
3. washwashed with 5% sodium hydroxide solution
4. dry with materialwith water and dried over magnesium sulfate
5. customThe solution obtained
6. concentrationis concentrated under reduced pressure and 3.42 g of the expected compound