Benzoyl chloride, 2-chloro-4-(methylsulfonyl)- → Vismodegib

HRID 1230995Notes

Reaction equation

HRID 1230995 reaction equation
[Cl:15][c:16]1[c:17]([C:18](=[O:19])[Cl:20])[cH:21][cH:22][c:23]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:24]1.[Cl:1][c:2]1[c:3](-[c:9]2[n:10][cH:11][cH:12][cH:13][cH:14]2)[cH:4][c:5]([NH2:6])[cH:7][cH:8]1>>[Cl:1][c:2]1[c:3](-[c:9]2[n:10][cH:11][cH:12][cH:13][cH:14]2)[cH:4][c:5]([NH:6][C:18]([c:17]2[c:16]([Cl:15])[cH:24][c:23]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:22][cH:21]2)=[O:19])[cH:7][cH:8]1

Participants

3

Reactant 2

HCID 11128804Benzoyl chloride, 2-chloro-4-(methylsulfonyl)-HCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 24776445Vismodegib

Sources & evidence

ORD record
ord-99b86e352dc8409eaae093dd829160e7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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