Acetate → 1-(5'-Fluoro-2'-methoxy-biphenyl-4-yl)-ethylamine

HRID 1231645Notes

Reaction equation

HRID 1231645 reaction equation
[Br:13][c:14]1[cH:15][cH:16][c:17]([CH:20]([CH3:21])[NH2:22])[cH:18][cH:19]1.[C:26]([O-:27])(=[O:28])[CH3:29].[C:31]([O-:32])(=[O:33])[CH3:34].[CH3:24][OH:25].[F:1][c:2]1[cH:3][cH:4][c:5]([O:11][CH3:12])[c:6]([B:8]([OH:9])[OH:10])[cH:7]1.[OH2:23].[Pd+2:30]>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:11][CH3:12])[c:6](-[c:14]2[cH:15][cH:16][c:17]([CH:20]([CH3:21])[NH2:22])[cH:18][cH:19]2)[cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 887MethanolHCID 962WaterHCID 911751-(4-Bromophenyl)ethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27826735-Fluoro-2-methoxyphenylboronic acid

Product 1

HCID 610332941-(5'-Fluoro-2'-methoxy-biphenyl-4-yl)-ethylamine

Sources & evidence

ORD record
ord-2a45b854e8b74c23a603c7064166257a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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