2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 8-(Isobutylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[CH2:1]([CH:2]([CH3:3])[CH3:4])[S:5](=[O:6])(=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13][NH:14][C:15]2=[O:16])[CH2:17][CH2:18]1.[F:19][C:20]([CH:21]([OH:22])[c:23]1[cH:24][cH:25][c:26]([I:29])[cH:27][cH:28]1)([F:30])[F:31]>>[CH2:1]([CH:2]([CH3:3])[CH3:4])[S:5](=[O:6])(=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([CH2:12][CH2:13][N:14]([c:26]3[cH:25][cH:24][c:23]([CH:21]([C:20]([F:19])([F:30])[F:31])[OH:22])[cH:28][cH:27]3)[C:15]2=[O:16])[CH2:17][CH2:18]1Participants
3
Sources & evidence
- ORD record
- ord-61b89aaa95c2469c99ed9c1996cac7b3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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