2,6-Difluoro-4-methoxybenzeneboronic acid → 1-Cyclohexyl-3-(3,5-dichloro-2',6'-difluoro-4'-methoxy-biphenyl-4-ylmethyl)-pyrrolidin-2-one

HRID 1233735Notes

Reaction equation

HRID 1233735 reaction equation
[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[cH:8][c:9]([Cl:27])[c:10]([CH2:14][CH:15]2[C:16](=[O:26])[N:17]([CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[CH2:18][CH2:19]2)[c:11]([Cl:13])[cH:12]1)(=[O:28])=[O:29].[F:30][c:31]1[c:32]([B:40]([OH:41])[OH:42])[c:33]([F:39])[cH:34][c:35]([O:37][CH3:38])[cH:36]1>>[c:7]1(-[c:32]2[c:31]([F:30])[cH:36][c:35]([O:37][CH3:38])[cH:34][c:33]2[F:39])[cH:8][c:9]([Cl:27])[c:10]([CH2:14][CH:15]2[C:16](=[O:26])[N:17]([CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[CH2:18][CH2:19]2)[c:11]([Cl:13])[cH:12]1

Participants

3

Reactant 2

HCID 162174242,6-Difluoro-4-methoxybenzeneboronic acidHCID 592994213,5-Dichloro-4-((1-cyclohexyl-2-oxopyrrolidin-3-yl)methyl)phenyl trifluoromethanesulfonate

Product 1

HCID 684724681-Cyclohexyl-3-(3,5-dichloro-2',6'-difluoro-4'-methoxy-biphenyl-4-ylmethyl)-pyrrolidin-2-one

Sources & evidence

ORD record
ord-f440dbcab6f54fb885f89f6fbd9a9229
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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