1-(3-Aminopropyl)-2-pyrrolidinone → 8-Indan-5-yl-5-oxo-2-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Participants

Reaction Steps

Using the procedure outlined in Example 1 Step F, the title compound was prepared from 1-(3-amino-propyl)-pyrrolidin-2-one and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(Step E) 25 mg, 0.052 mmol). 17 mg of 8-Indan-5-yl-5-oxo-2-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.25 (s, 1H), 8.46 (s, 1H), 7.33 (d, J=7.7 Hz, 1H), 7.23 (s, 1H), 7.16 (d, J=7.7 Hz, 1H), 6.26 (br, 1H), 4.37 (q, J=7.3 Hz, 2H), 3.36 (m, 2H), 3.27 (m, 2H), 3.00 (m, 4H), 2.37 (t, J=7.9 Hz, 2H), 2.18 (m, 2H), 2.00 (m, 2H), 1.60 (m, 4H), 1.38 (t, J=7.3 Hz).

Provenance & Evidence