2-Amino-5-bromopyridine → N-(5-bromo-2-pyridinyl)-3-cyclohexyl-2-(3-oxo-1H-isoindol-2-yl)propanamide

HRID 1234604Notes

Reaction equation

HRID 1234604 reaction equation
[CH:1]1([CH2:7][CH:8]([C:9](=[O:10])[OH:11])[N:12]2[C:13](=[O:21])[c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[CH2:20]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[CH:30]1([CH2:31][CH:32]([N:33]2[CH2:34][c:35]3[c:36]([cH:37][cH:38][cH:39][cH:40]3)[C:41]2=[O:42])[C:43]([NH:44][c:45]2[s:46][cH:47][cH:48][n:49]2)=[O:50])[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]1.[NH2:22][c:23]1[n:24][cH:25][c:26]([Br:29])[cH:27][cH:28]1>>[CH:1]1([CH2:7][CH:8]([C:9](=[O:11])[NH:22][c:23]2[n:24][cH:25][c:26]([Br:29])[cH:27][cH:28]2)[N:12]2[C:13](=[O:21])[c:14]3[cH:15][cH:16][cH:17][cH:18][c:19]3[CH2:20]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 706222-Amino-5-bromopyridineHCID 35710923-cyclohexyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acidHCID 184022003-cyclohexyl-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)propanamide

Product 1

HCID 18402198N-(5-bromo-2-pyridinyl)-3-cyclohexyl-2-(3-oxo-1H-isoindol-2-yl)propanamide

Sources & evidence

ORD record
ord-0ab2713f6b954d569d64bf17e15eaaa9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…