Acetic Acid → 4-[1-(4-Aminobutyl)piperidin-4-yl]butyramide

HRID 1234944Notes

Reaction equation

HRID 1234944 reaction equation
[CH3:31][C:32](=[O:33])[OH:34].[CH3:35][CH2:36][OH:37].[NH2:29][NH2:30].[O:1]=[C:2]1[N:3]([CH2:12][CH2:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH:19]([CH2:22][CH2:23][CH2:24][C:25](=[O:26])[NH2:27])[CH2:20][CH2:21]2)[C:10](=[O:11])[CH:5]2[CH:4]1[CH:9]=[CH:8][CH:7]=[CH:6]2.[OH2:28]>>[NH2:3][CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][CH:19]([CH2:22][CH2:23][CH2:24][C:25](=[O:26])[NH2:27])[CH2:20][CH2:21]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 962WaterHCID 9321HydrazineHCID 668109714-{1-[4-(1,3-Dioxo-1,3,3a,7a-tetrahydroisoindol-2-yl)butyl]piperidin-4-yl}-butyramide

Product 1

HCID 668109774-[1-(4-Aminobutyl)piperidin-4-yl]butyramide

Sources & evidence

ORD record
ord-90c6e286f0454deaabb216113c285130
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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