Dichloromethane → 5-Chloro-1-{2-oxo-1-phenyl-2-[3-(4-propylpiperazin-1-yl)pyrrolidin-1-yl]-ethyl}-1,3-dihydrobenzimidazol-2-one

HRID 1235431Notes

Reaction equation

HRID 1235431 reaction equation
[CH2:32]([CH2:33][CH3:34])[N:35]1[CH2:36][CH2:37][N:38]([CH:41]2[CH2:42][NH:43][CH2:44][CH2:45]2)[CH2:39][CH2:40]1.[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH:10]([C:11](=[O:12])[OH:13])[c:14]3[cH:15][cH:16][cH:17][cH:18][cH:19]3)[c:7](=[O:9])[nH:8]2)[cH:20][cH:21]1.[Cl:46][CH2:47][Cl:48].[OH:22][n:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[n:30][n:31]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH:10]([C:11](=[O:12])[N:43]3[CH2:42][CH:41]([N:38]4[CH2:37][CH2:36][N:35]([CH2:32][CH2:33][CH3:34])[CH2:40][CH2:39]4)[CH2:45][CH2:44]3)[c:14]3[cH:15][cH:16][cH:17][cH:18][cH:19]3)[c:7](=[O:9])[nH:8]2)[cH:20][cH:21]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 757711-HydroxybenzotriazoleHCID 24901021(5-Chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)phenyl-acetic acidHCID 667546611-Propyl-4-pyrrolidin-3-ylpiperazine

Product 1

HCID 667550625-Chloro-1-{2-oxo-1-phenyl-2-[3-(4-propylpiperazin-1-yl)pyrrolidin-1-yl]-ethyl}-1,3-dihydrobenzimidazol-2-one

Sources & evidence

ORD record
ord-6cb3c2ce92254896b17d9b3457c1b026
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…