Acetone → (3-(4-Cyano-4-(2,4-difluorophenyl)piperidin-1-yl)propyl)carbamic acid tert-butyl ester
Reaction equation
[C:17]([CH3:18])([CH3:19])([CH3:20])[O:21][C:22](=[O:23])[NH:24][CH2:25][CH2:26][CH2:27][Br:28].[CH3:31][C:32](=[O:33])[CH3:34].[F:1][c:2]1[c:3]([C:9]2([C:15]#[N:16])[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[I-:30].[Na+:29]>>[F:1][c:2]1[c:3]([C:9]2([C:15]#[N:16])[CH2:10][CH2:11][N:12]([CH2:27][CH2:26][CH2:25][NH:24][C:22]([O:21][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:23])[CH2:13][CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-3c47e15402bf466591cfcb8b2951052c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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