Methyl (2'-fluoro-4'-hydroxy-1,1'-biphenyl-4-yl)acetate → Methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-2'-fluoro-1,1'-biphenyl-4-yl)acetate

HRID 1236636Notes

Reaction equation

HRID 1236636 reaction equation
[CH3:20][O:21][CH:22]([c:23]1[c:24]([CH2:37][OH:38])[cH:25][cH:26][c:27]([C:33]([F:34])([F:35])[F:36])[c:28]1[O:29][CH2:30][O:31][CH3:32])[O:39][CH3:40].[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][c:12]([CH2:15][C:16](=[O:17])[O:18][CH3:19])[cH:13][cH:14]2)[cH:4][cH:5][c:6]([OH:8])[cH:7]1>>[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][c:12]([CH2:15][C:16](=[O:17])[O:18][CH3:19])[cH:13][cH:14]2)[cH:4][cH:5][c:6]([O:8][CH2:37][c:24]2[c:23]([CH:22]([O:21][CH3:20])[O:39][CH3:40])[c:28]([O:29][CH2:30][O:31][CH3:32])[c:27]([C:33]([F:34])([F:35])[F:36])[cH:26][cH:25]2)[cH:7]1

Participants

3

Reactant 2

HCID 57992143Methyl (2'-fluoro-4'-hydroxy-1,1'-biphenyl-4-yl)acetateHCID 67119352[2-(Dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)phenyl]methanol

Product 1

HCID 86617405Methyl (4'-{[2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl]oxy}-2'-fluoro-1,1'-biphenyl-4-yl)acetate

Sources & evidence

ORD record
ord-65cd6befe7d84399a9eaae28ffd18000
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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