2-Amino-3-methoxy-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one → 2-[5-Chloro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-3-methoxy-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one

HRID 1236807Notes

Reaction equation

HRID 1236807 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([O:21][CH3:22])[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1.[NH2:24][c:25]1[c:26]([O:38][CH3:39])[cH:27][c:28]2[c:29]([cH:37]1)[CH2:30][CH2:31][O:32][C:33](=[O:36])[N:34]2[CH3:35]>>[c:2]1([NH:24][c:25]2[c:26]([O:38][CH3:39])[cH:27][c:28]3[c:29]([cH:37]2)[CH2:30][CH2:31][O:32][C:33](=[O:36])[N:34]3[CH3:35])[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([O:21][CH3:22])[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 672646482-Amino-3-methoxy-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-oneHCID 86633851(2,5-Dichloropyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 672641722-[5-Chloro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-3-methoxy-5-methyl-8,9-dihydro-5H-7-oxa-5-aza-benzocyclohepten-6-one

Sources & evidence

ORD record
ord-1c1b3ff61123416fa5a831c27c12a59f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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