N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2,6-difluorophenyl)-4-(3-methyl-4'-trifluoromethoxybiphenyl-4-yl)-5,6-dihydro(4H)1,3-oxazine
Reaction equation
[F:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]([CH2:8][CH2:9][OH:10])[c:11]2[c:12]([CH3:28])[cH:13][c:14](-[c:17]3[cH:18][cH:19][c:20]([O:23][C:24]([F:25])([F:26])[F:27])[cH:21][cH:22]3)[cH:15][cH:16]2)[c:29]([F:33])[cH:30][cH:31][cH:32]1.[F:34][c:35]1[cH:36][cH:37][cH:38][c:39]([F:40])[c:41]1[C:42]([NH:43][CH:44]([c:45]1[cH:46][cH:47][c:48]([Cl:49])[cH:50][cH:51]1)[CH2:52][CH2:53][OH:54])=[O:55]>>[F:1][c:2]1[c:3]([C:4]2=[N:6][CH:7]([c:11]3[c:12]([CH3:28])[cH:13][c:14](-[c:17]4[cH:18][cH:19][c:20]([O:23][C:24]([F:25])([F:26])[F:27])[cH:21][cH:22]4)[cH:15][cH:16]3)[CH2:8][CH2:9][O:10]2)[c:29]([F:33])[cH:30][cH:31][cH:32]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-f15116b8610a4291a6b534313e18be1c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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