Acetic Acid → Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

HRID 1237219Notes

Reaction equation

HRID 1237219 reaction equation
[C:14]1(=[O:18])[CH2:15][CH2:16][CH2:17]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[C:23]([BH3-:24])#[N:25].[CH3:19][C:20](=[O:21])[OH:22].[CH3:27][OH:28].[Na+:26]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([CH:14]2[CH2:15][CH2:16][CH2:17]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 887MethanolHCID 923Sodium ionHCID 14496CyclobutanoneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 498716Cyano-borohydride

Product 1

HCID 57423951Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

Sources & evidence

ORD record
ord-1c04648a1b494e61956f28f5858308f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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