(RS)-5,6-difluoro-1-methyl-2-piperidin-2-ylmethyl-1H-benzoimidazole → (RS)-1-[2-(5,6-Difluoro-1-methyl-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone

HRID 1237377Notes

Reaction equation

HRID 1237377 reaction equation
[F:18][c:19]1[cH:20][c:21]2[c:22]([n:23]([CH3:33])[c:24]([CH2:26][CH:27]3[NH:28][CH2:29][CH2:30][CH2:31][CH2:32]3)[n:25]2)[cH:34][c:35]1[F:36].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:15](=[O:16])[OH:17])[n:10][c:11]([CH2:13][OH:14])[s:12]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:15](=[O:17])[N:28]3[CH:27]([CH2:26][c:24]4[n:23]([CH3:33])[c:22]5[c:21]([cH:20][c:19]([F:18])[c:35]([F:36])[cH:34]5)[n:25]4)[CH2:32][CH2:31][CH2:30][CH2:29]3)[n:10][c:11]([CH2:13][OH:14])[s:12]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 23146341(RS)-5,6-difluoro-1-methyl-2-piperidin-2-ylmethyl-1H-benzoimidazoleHCID 234501385-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acid

Product 1

HCID 23146238(RS)-1-[2-(5,6-Difluoro-1-methyl-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone

Sources & evidence

ORD record
ord-1f6f87d46c964cc5b02fce1c97a2f46d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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