Sodium ion → 6-(3-Fluoro-benzyloxy)-2-(2-methoxy-1-methyl-ethyl)-3,4-dihydro-2H-isoquinolin-1-one

HRID 1237541Notes

Reaction equation

HRID 1237541 reaction equation
[CH3:27][I:28].[F:1][c:2]1[cH:3][c:4]([CH2:5][O:6][c:7]2[cH:8][c:9]3[c:14]([cH:15][cH:16]2)[C:13](=[O:17])[N:12]([CH:18]([CH2:19][OH:20])[CH3:21])[CH2:11][CH2:10]3)[cH:22][cH:23][cH:24]1.[H-:25].[Na+:26].[OH2:29]>>[F:1][c:2]1[cH:3][c:4]([CH2:5][O:6][c:7]2[cH:8][c:9]3[c:14]([cH:15][cH:16]2)[C:13](=[O:17])[N:12]([CH:18]([CH2:19][O:20][CH3:27])[CH3:21])[CH2:11][CH2:10]3)[cH:22][cH:23][cH:24]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 962WaterHCID 6328Methyl iodideHCID 166653HydrideHCID 226419476-(3-Fluoro-benzyloxy)-2-(2-hydroxy-1-methyl-ethyl)-3,4-dihydro-2H-isoquinolin-1-one

Product 1

HCID 226419416-(3-Fluoro-benzyloxy)-2-(2-methoxy-1-methyl-ethyl)-3,4-dihydro-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-dd33bc77801f48eab7d0fd34b5d80083
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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