{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → tert-Butyl 1-(4-(8-chloro-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutylcarbamate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:18]3[c:19](=[O:20])[c:21]4[c:22]([cH:23][cH:24][c:25]([F:26])[cH:27]4)[o:28][c:29]3-[c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1)=[O:36].[Cl:37][c:38]1[n:39][cH:40][cH:41][c:42]2[c:43]1[o:44][c:45](-[c:50]1[cH:51][cH:52][cH:53][cH:54][cH:55]1)[c:46]([I:49])[c:47]2=[O:48]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:12]2[cH:13][cH:14][c:15](-[c:46]3[c:45](-[c:50]4[cH:51][cH:52][cH:53][cH:54][cH:55]4)[o:44][c:43]4[c:38]([Cl:37])[n:39][cH:40][cH:41][c:42]4[c:47]3=[O:48])[cH:16][cH:17]2)[CH2:9][CH2:10][CH2:11]1)=[O:36]Participants
3
Sources & evidence
- ORD record
- ord-b487050a5fe64d4399fc71ade4443ad5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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