関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline | HCID 13219441 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4,4-Dimethyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 57423310 | — |
反応手順
1b (0.762 g, 4.73 mmol), ortho-fluoronitrobenzene (0.88 g, 5.67 mmol, 1.19 eq), and 2,4,6-collidine (0.66 mL, 1.05 eq) were pre-stirred 40s in a conical microwave container. It was then heated with stirring at a Personal Chemistry Microwave reactor with normal absorption at 250° C. for 1 h. The crude mixture was dissolved in CHCl3, and was purified by flash chromatography (hexanes/EtOAc) to give 0.66 g of crude 1c. LC-MS ESI 283 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728008B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-6f4b0b70237f463091d7218d522edefa |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
