反应详情

温度

175 °C

To 2c (317 mg, 2.12 mmol) was added 1-fluoro-2-nitrobenzene (200 mg, 1.42 mmol). The reaction mixture was stirred at 175° C. for 8 h. The reaction mixture was diluted with CH2Cl2 and washed with 1N HCl and dried over Na2SO4. The solvent was evaporated under reduced pressure and purified by column chromatography using 0 to 10% EtOAc in hexane over 30 min as eluting solvent to afford 2d (360 mg, 95%) as an oil. MS (ES) m/z 269 [M+H]+.

1. washwashed with 1N HCl
2. dry with materialdried over Na2SO4
3. customThe solvent was evaporated under reduced pressure
4. custompurified by column chromatography
5. customover 30 min
6. washas eluting solvent