1-[2-(Methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidine-2-carboxylic acid → tert-butyl 2-[5-[6-[1-[2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,11,14(19),15,17-octaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate
Reaction equation
[CH3:100][O:101][C:102]([NH:103][CH:104]([CH:105]([CH3:106])[CH3:107])[C:108]([N:109]1[CH:110]([CH3:111])[CH2:112][CH2:113][CH:114]1[C:115]([OH:116])=[O:117])=[O:118])=[O:119].[CH3:1][O:2][CH2:3][CH:4]1[CH2:5][N:6]([C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[CH:14]([C:15]([O:16][CH2:17][C:18]([c:19]2[cH:20][cH:21][c:22]3[c:37]([cH:38]2)[CH2:36][O:35][c:34]2[c:23]-3[cH:24][c:25]3[c:32]([cH:33]2)[C:30](=[O:31])[CH:28]([Br:29])[CH2:27][CH2:26]3)=[O:39])=[O:40])[CH2:41]1.[CH3:42][O:43][C:44](=[O:45])[NH:46][CH:47]([CH:48]([CH3:49])[CH3:50])[C:51](=[O:52])[N:53]1[CH:54]([c:59]2[n:60][c:61]3[c:62]([nH:63]2)-[c:64]2[cH:65][c:66]4[c:67]([cH:68][c:69]2[CH2:70][CH2:71]3)-[c:72]2[cH:73][cH:74][c:75](-[c:80]3[cH:81][n:82][c:83]([CH:85]5[N:86]([C:93](=[O:94])[O:95][C:96]([CH3:97])([CH3:98])[CH3:99])[CH2:87][CH:88]([CH2:90][O:91][CH3:92])[CH2:89]5)[nH:84]3)[cH:76][c:77]2[CH2:78][O:79]4)[CH2:55][CH2:56][CH:57]1[CH3:58]>>[CH3:42][O:43][C:44](=[O:45])[NH:46][CH:47]([CH:48]([CH3:49])[CH3:50])[C:51](=[O:52])[N:53]1[CH:54]([c:59]2[n:60][c:61]3[c:62]([nH:63]2)-[c:64]2[cH:65][c:66]4[c:67]([cH:68][c:69]2[CH2:70][CH2:71]3)-[c:72]2[cH:73][cH:74][c:75](-[c:80]3[cH:81][n:82][c:83]([CH:85]5[N:86]([C:93](=[O:94])[O:95][C:96]([CH3:97])([CH3:98])[CH3:99])[CH2:87][CH:88]([CH2:90][O:91][CH3:92])[CH2:89]5)[nH:84]3)[cH:76][c:77]2[CH2:78][O:79]4)[CH2:55][CH2:56][CH2:57]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-a41526a498fd41c1a4a887384bacf9f4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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