4-aminomethyl-N-(2,2,2-trifluoroethyl)-benzamide → 7-chloro-3-(2,2,2-trifluoroacetyl)-6-[4-(2,2,2-trifluoroethyl-aminocarbonyl)-benzylamino]-2,3,4,5-tetrahydro-1H-benzo[d]azepine

HRID 124031Notes

Reaction equation

HRID 124031 reaction equation
[Cl:1][c:2]1[c:3]([O:19][S:20]([C:21]([F:22])([F:23])[F:24])(=[O:25])=[O:26])[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2.[NH2:27][CH2:28][c:29]1[cH:30][cH:31][c:32]([C:33](=[O:34])[NH:35][CH2:36][C:37]([F:38])([F:39])[F:40])[cH:41][cH:42]1>>[Cl:1][c:2]1[c:3]([NH:27][CH2:28][c:29]2[cH:30][cH:31][c:32]([C:33](=[O:34])[NH:35][CH2:36][C:37]([F:38])([F:39])[F:40])[cH:41][cH:42]2)[c:4]2[c:5]([cH:17][cH:18]1)[CH2:6][CH2:7][N:8]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 246898914-aminomethyl-N-(2,2,2-trifluoroethyl)-benzamideHCID 574477477-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethylsulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 866296177-chloro-3-(2,2,2-trifluoroacetyl)-6-[4-(2,2,2-trifluoroethyl-aminocarbonyl)-benzylamino]-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Sources & evidence

ORD record
ord-c0ef5d5cbf93424b9963059451acf54e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…