Hydrochloric Acid → [1-(Benzoylaminomethyl)-2-m-tolyloxyethyl]carbamic acid benzyl ester

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Reaction Steps

To (2-benzyloxycarbonylamino-3-m-tolyloxypropyl)carbamic acid tert-butyl ester (220 mg) obtained in Step 2 was added 4N solution (2 ml) of hydrogen chloride in dioxane, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated, dichloromethane (7 ml), benzoyl chloride (96 μl) and triethylamine (265 μl) were added to the obtained solid, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with ethyl acetate and, after washing with water, the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated and the obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give [1-(benzoylaminomethyl)-2-m-tolyloxyethyl]carbamic acid benzyl ester (200 mg).

Provenance & Evidence