Dimethyl Sulfoxide → Tert-butyl 2-[6-[(3-methylphenyl)carbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

HRID 1240466Notes

Reaction equation

HRID 1240466 reaction equation
[CH2:18]1[N:19]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:20][CH:21]2[CH:22]1[CH2:23][NH:24][CH2:25]2.[CH3:39][S:40]([CH3:41])=[O:42].[Cl:1][c:2]1[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([CH3:17])[cH:14][cH:15][cH:16]2)[n:7]1.[Na+:33].[Na+:34].[O-:35][C:36](=[O:37])[O-:38]>>[c:2]1([N:24]2[CH2:23][CH:22]3[CH2:18][N:19]([C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:20][CH:21]3[CH2:25]2)[cH:3][n:4][cH:5][c:6]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13]([CH3:17])[cH:14][cH:15][cH:16]2)[n:7]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 27554286-Chloro-N-(m-tolyl)pyrazine-2-carboxamideHCID 4142526Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate

Product 1

HCID 67265821Tert-butyl 2-[6-[(3-methylphenyl)carbamoyl]pyrazin-2-yl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-084db29d35e04dbd919fa1ff202ebd93
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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