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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 124057Generated: October 26, 2026

Toluene → 2-Chloro-6-methyl-isonicotinic acid tert-butyl ester

https://huagongshe.com/reaction/124057

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantDimethylformamideHCID 6228—
ReactantDichloromethaneHCID 6344—
Reactanttert-ButanolHCID 6386—
ReactantTriethylamineHCID 8471—
Reactant4-(Dimethylamino)pyridineHCID 14284—
ReactantThionyl ChlorideHCID 24386—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Product2-Chloro-6-methyl-isonicotinic acid tert-butyl esterHCID 86040366—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-eef4bfdd39434edaaa1477263f1d5459
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)