5-(2,2-Difluoro-ethoxy)-pyridine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-5-(2,2-difluoroethoxy)pyridine-2-carboxamide
Reaction equation
[F:19][CH:20]([CH2:21][O:22][c:23]1[cH:24][cH:25][c:26]([C:29](=[O:30])[OH:31])[n:27][cH:28]1)[F:32].[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:29]([c:26]1[cH:25][cH:24][c:23]([O:22][CH2:21][CH:20]([F:19])[F:32])[cH:28][n:27]1)=[O:30]Participants
3
Sources & evidence
- ORD record
- ord-7eebc18ad3934685ab60a57e16ab4c23
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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