反应详情

To t-butyl (1S)-2-(benzyloxy)-1-[(3-methylphenoxy)methyl]ethylcarbamate (3.8 g) obtained in Step 2 of Example 15 were added 10% palladium-carbon (wet, 1 g) and ethanol (30 ml), and the mixture was stirred for 2 days under hydrogen atmosphere. After celite filtration, the solvent was evaporated. The obtained crude product was purified by silica gel chromatography (ethyl acetate-hexane) to give the title compound (3.0 g).

1. filtrationAfter celite filtration
2. customthe solvent was evaporated
3. customThe obtained crude product
4. customwas purified by silica gel chromatography (ethyl acetate-hexane)